I listen to the Preston and Steve show.
http://www.wmmr.com/shows/preston-and-steve/media/
They're the #1 morning radio show in Philadelphia and pretty high/recommended in the comedy section of Itunes podcasts. They are hilarious and awesome.
Preston is the captain of the ship, he runs the show. Steve is a comedian whose improv skills are among the best. Kathy does the traffic and chimes in when something interests her. Casey is the producer and makes a fool of himself all the time. Nick handles the website and makes strange sounds unintentionally. Marisa is the behind the scenes producer that makes sure the interns do their job.
Preston and Steve themselves have been working together for almost 18 years and the chemistry is amazing. They don't mention it much anymore but they ask anyone skeptical of their show to just listen every day for one week, and then you'll know if you like them or not.
I listen religiously through Podcasts.